Genetics Programme

The introduction of advanced diagnostic and genetic technologies during the IVF/ICSI process significantly improves success rates for pregnancies. Chromosomal abnormalities are the number one cause of failed IVF/ICSI procedures and miscarriage especially when also considering the woman’s age.

Pre-implantation genetic screening (PGS) allows for the assessment of all 23 chromosome pairs in the embryo. Embryos are screened for any genetic abnormalities before they are selected for transfer. Genetically normal embryos have a better chance of implantation and carry a lower risk for miscarriage.

Pre-implantation genetic diagnosis (PGD) involves testing for specific chromosomal changes that are often linked to the onset of specific diseases, for example cystic fibrosis.

We have a dedicated team of consultants, embryologists, and genetic counsellors who have extensive expertise in this field. Bedaya has become a pioneer in genetic research within Egypt and the Middle East and is now frequently used as a referral centre for PGD testing.

 

Karyomapping

Who is karyomapping for?

You may know that you are a carrier of a genetic disorder because you already have a child who is affected or you may be aware that you have a family history for the disorder and have had your DNA tested to confirm that you carry a defective gene.

Karyomapping is a new technique that allows couples, known to be carriers of an inherited condition, to avoid passing on that disorder to their offspring. The technique works by screening embryos for any potential genetic disorder prior to implantation in the uterus. This technique is called preimplantation genetic diagnosis or PGD for short.

PGD significantly reduces the chance that a foetus will be affected by the genetic disorder.

 

Why is IVF/ICSI required?

In order to carry out PGD in vitro fertilization IVF/ICSI is essential. This is because in order to screen embryos using PGD, several eggs must be collected from the ovaries and fertilized outside of the body (in vitro) in order to produce several embryos that we can screen. Each of the embryos can then be tested and some may have genetic disorders and some may be health, this way we can select only the healthy embryos for transfer.

 

How does karyomapping work?

Karyomapping is a technique that examines the chromosomes of the mother and father at 300,000 different points along the DNA strand. DNA is made up of 23 chromosomes and karyomapping searches through all 23 chromosomes along the DNA strand for any defects. This technique searches for features that are characteristic of the defective chromosome. Essentially, karyomapping finds a fingerprint that is unique to the chromosomes that carries the defective gene, and if that fingerprint matches any parts of the DNA sequence it alerts us that there is a defective portion. Whenever the fingerprint is seen in an embryo it means that it has inherited the chromosome carrying the defective gene.

If the fingerprint characteristic of the chromosome carrying the defective gene is not detected then it can be confirmed that the embryo has inherited normal copies of the gene and is therefore likely to be free of the disorder. Embryos of this type are good candidates for transfer to the mother’s uterus.  

Endoscopy Department