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Preimplantation genetic testing (PGT-M)

Preimplantation genetic testing (PGT-M)

Preimplantation Genetic Testing for Monogenic disorders (PGT-M). This test helps couples with a family history of genetic diseases to not pass them to their offspring. PGT-M which was previously known as PGD,tests hereditary genetic diseases in artificially fertilized embryos, which allows doctors to transfer only healthy embryos inside the womb.

 

Preimplantation Genetic Test for Monogenic Disorders (PGT-M)

The genetic test before implantation analyzes the DNA of each fertilized embryo, thus detecting if one of the embryos is a carrier of the genetic disease and is excluded. This test (PGT-M) is prescribed to a specific group of couples who suffer or are at risk of transmitting a single gene disease.

Monogenic diseases include:

  • Cystic fibrosis disease.
  • Fragile X syndrome disease.
  • Muscular dystrophy disease.
  • Huntington's disease.

PGT-M is formerly known as PGD, is customized according to the patient's situation and which type of single-gene disorder may be transferred to the offspring.

 

PGT-M benefits

  • Increased chance of delivering a healthy baby free from a disease caused by a single gene mutation that is known to be carried on, in one of or both the parents’ families.
  • Doctors can apply PGT-A and PGT-M tests on the same biopsy taken from the embryos for genetic testing to detect chromosomal and single-gene disorders simultaneously.
  • PGT-M test can detect most monogenic disorders.

 

PGT-M procedure

  • Couples should book a consultation at Bedaya hospital to review the medical family history and the inherited disorders.
  • The doctors will ask for pre-PGT-M test which takes about 6 weeks.
  • A biopsy for genetic testing is taken from the embryos at day 3 or day 5 (blastocyst phase) to be examine and analyze the DNA of the cells.
  • The embryologist will come up with PGT test reports with results within15 days; the time needed to analyze the DNA in a special embryos lab.

Embryos free of monogenic disorders will be transferred for implantation